Published July 1982 | Version v1
Journal article Metadata-only

Common proviral integration sites in C57BL mouse lymphomas induced by RadLV and absence of novel proviral sequences in radiogenic lymphoma DNA

Creators

  • 1. Centre d'Etude de l'Energie Nucleaire, Mol (Belgium)
  • 2. Universite de Liege au Sart Tilman, Liege (Belgium)

Description

Radiation leukemia virus (RadlV)-induced lymphomas of C57BL mice display the appearance of novel proviral sequences at common sites of their DNAs. These results are compatible with the hypothesis of viral oncogenesis by promotor insertion. Radiation-induced tumors do not acquire detectable novel provirus, suggesting that activation of a transforming gene proceeds by a mechanism distinct from the former

Abstract (French)

Les lymphomes induits chez des souris C57BL par le virus des radioleucoses murines (RadlV) presentent de nouvelles sequences provirales en des sites communs de leurs ADN. Ces resultats sont compatibles avec l'hypothese d'une oncogenese virale par l'insertion d'un promoteur. Les tumeurs radio-induites n'acquierent pas de nouveau provirus decelable. Ce fait suggere que l'activation d'un gene transformant par irradiation resulte d'un mecanisme distinct de celui qui precede

Additional details

Additional titles

Original title (French)
Sites communs d'integration de provirus dans les lymphomes induits chez des souris C57BL par le virus des radioleucoses murines (RadlV) et absence de nouvelles sequences provirales dans l'ADN des lymphomes radio-induits

Publishing Information

Journal Title
C. R. Seances Soc. Biol. Fil.
Journal Volume
176
Journal Issue
3
Series
C. R. Seances Soc. Biol. Fil.
Journal Page Range
411-419
ISSN
0037-9026

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
14717263
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; DNA; LEUKEMOGENESIS; LYMPHOMAS; MICE; VIRUSES
Descriptors DEC
ANIMALS; BIOLOGICAL EFFECTS; CARCINOGENESIS; DISEASES; MAMMALS; MICROORGANISMS; NEOPLASMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PARASITES; PATHOGENESIS; RADIATION EFFECTS; RODENTS; VERTEBRATES