Published August 2021 | Version v1
Journal article Metadata-only

Evaluating the radioprotective effect of Cimetidine, IMOD, and hybrid radioprotectors agents: An in-vitro study

Creators

  • 1. Medical Imaging Department, Aalinasab Hospital, Social Security Organization (SSO), Tabriz (Iran, Islamic Republic of)
  • 2. Radiology Group, Shahid Beheshti of University of Paramedical Sciences, Tehran (Iran, Islamic Republic of)
  • 3. Medical Physics Department, Tabriz University of Medical Sciences, Tabriz (Iran, Islamic Republic of)
  • 4. Department of Medical Radiation Engineering, Shahid Beheshti University, Tehran (Iran, Islamic Republic of)
  • 5. Department of Medical Physics, Isfahan University of Medical Sciences, Isfahan (Iran, Islamic Republic of)
  • 6. Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of)
  • 7. Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran, University of Medical Sciences, Tehran (Iran, Islamic Republic of)
  • 8. Department of Anesthesiology, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY (United States)
  • 9. Department of Medical Physics Radiobiology and Radiation Protection, School of Medicine, Babol University of Medical Sciences, Babol (Iran, Islamic Republic of)
  • 10. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj (Iran, Islamic Republic of)

Description

Highlights: • The radio-protective effect of Cimetidine, IMOD, and their combination was assessed. • Micronucleus assay was used to show the amount of cellular damage. • The micronucleus frequencies were significantly reduced in irradiated groups. • The combination of the agents showed the highest level of radioprotective. There are various radioprotective agents with different mechanisms that help to decrease ionizing radiation side effects. The radioprotective effect of Cimetidine and IMOD was assessed individually and compared with the hybrid radioprotectors agents (HRPAs-IMOD and Cimetidine) on human lymphocyte cells.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.apradiso.2021.109760

Additional details

Identifiers

DOI
10.1016/j.apradiso.2021.109760;
PII
S0969804321001652;

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
174
Journal Page Range
vp.
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
54055707
Subject category
S61: RADIATION PROTECTION AND DOSIMETRY;
Descriptors DEI
COMPARATIVE EVALUATIONS; DAMAGE; HUMANS; HYBRIDIZATION; IN VITRO; IONIZING RADIATIONS; IRRADIATION; LYMPHOCYTES; RADIATION PROTECTION; RADIOPROTECTIVE SUBSTANCES; SIDE EFFECTS
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DRUGS; EVALUATION; LEUKOCYTES; MAMMALS; MATERIALS; PRIMATES; RADIATIONS; RESPONSE MODIFYING FACTORS; SOMATIC CELLS; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2021 Elsevier Ltd. All rights reserved.