Pathophysiology of recent advances in current thyroid function testing
Creators
- 1. Medizinische Hochschule Hannover (Germany, F.R.). Abt. fuer Klinische Endokrinologie
Description
In the first chapter I have discussed thyroid function and thyroid status which is determined by thyroid gland function in secreting T4 and peripheral biotransformation of T4. The accuracy of a current in-vitro diagnostic strategy allows high reliability in clinical routine. More recent test procedures for iodothyronines and immunological phenomena need further evaluation. In another chapter the biotransformation of T4 to bioactive and regulatory iodothyronines with respect to possible clinical implications is discussed. Finally, the role of TBG for interpration of T4 and T3 concentrations is determined and more attention directed to its functional heterogeneity. (orig.)
Availability note (English)
MF available from INIS under the Report Number.Abstract (German)
Zunaechst werden Schilddruesenfunktion und Feststellung des Schilddruesenstatus anhand der T4-Ausscheidung und der periphaeren Biotransformation von T4 diskutiert. Die Genauigkeit eines derzeit angewandten diagnostischen in-vitro Verfahrens fuehrt hoher Zuverlaessigkeit der Resultate bei klinischen Routineuntersuchungen. Einige neuere Testmethoden fuer Jodthyronine und immunologische Vorgaenge beduerfen noch der Weiterentwicklung. Ein weiteres Kapitel behandelt die Biotransformation von T4 in bioaktive und regulierende Jodthyronine im Hinblick auf moegliche klinische Aspekte. Schliessich wird die Bedeutung des TBG bei der Interpretation von T4- und T3-Konzentrationen festgestellt und auf seine vielfaeltige funktionelle Bedeutung hingewiesen. (orig.)
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Additional details
Publishing Information
- Imprint Pagination
- 22 p.
- Report number
- AED-Conf--77-461-068
Conference
- Title
- International symposium on radioimmunoassay and related procedures in medicine.
- Dates
- 31 Oct - 4 Nov 1977.
- Place
- Berlin, Germany, F.R.
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 9395229
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- DIAGNOSTIC TECHNIQUES; ENDOCRINE DISEASES; IMMUNE REACTIONS; IMMUNOLOGY; IN VITRO; NUCLEAR MEDICINE; PATHOLOGICAL CHANGES; PHYSIOLOGY; RADIOIMMUNOASSAY; REVIEWS; TESTING; THYROID
- Descriptors DEC
- BODY; DISEASES; DOCUMENT TYPES; ENDOCRINE GLANDS; GLANDS; ISOTOPE APPLICATIONS; MEDICINE; ORGANS; TRACER TECHNIQUES
Optional Information
- Notes
- 17 figs.; 4 tabs.; 41 refs.
- Secondary number(s)
- IAEA-SM--220/206.