Effect of acute gamma irradiation on the behavioral parameters in white mice

High doses of ionizing radiation exposure have been shown to induce impairments in the limbic system. As hippocampal abnormalities have been linked to an impairment of behavioral functions, the present work aimed to investigate whether exposure to 5 Gy of ionizing radiation can develop behavioral deficits in adult mice. White mice (Mus musculus) were irradiated with ¹³⁷Cs. Experimental animals were tested in an ''open field'' maze over a period of 30 days after irradiation. A study of ''open field'' parameters revealed that gamma irradiation can be considered a radiobiological factor inducing anxiety and emotionality in mice. Using a laboratory white mouse model, we showed that ionizing radiation exposure could lead to increased anxiety-like behavior. A study of ''open field'' parameters revealed that gamma irradiation can be considered a radiobiological factor inducing anxiety and emotionality in mice. Behavioral changes can be considered as an integrated radiobiological effect, which includes both injury of the central nervous system, as well as implications for other organ systems in this process. (author)