Published October 2003 | Version v1
Journal article Metadata-only

A novel and efficient method for the technetium-99m labelling of disulfide compounds using a tetrahydroborate exchange resin

Creators

  • 1. Korea Atomic Energy Research Institute, HANARO Center, Daejeon (Korea, Republic of)
  • 2. Chungnam National Univ., Department of Fine Chemical Engineering and Chemistry, Daejeon (Korea, Republic of)

Description

A novel and efficient method for the technetium-99m labelling of disulfide compound 7 was established with high radiochemical purity in which tetrahydroborate exchange resin (BER) simultaneously carries out the reduction of 7, the reduction of [99mTc]pertechnetate and chelation of 7 with technetium-99m. The labelling occurs in a one-pot three-step procedure that is amenable to the preparation of 99mTc-radiopharmaceuticals. (author)

Additional details

Publishing Information

Journal Title
Bulletin of the Chemical Society of Japan
Journal Volume
76
Journal Issue
10
Journal Page Range
p. 1977-1981
ISSN
0009-2673

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
35003675
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CHELATES; DISULFIDES; EFFICIENCY; IMPURITIES; ION EXCHANGE MATERIALS; LABELLING; LIQUID COLUMN CHROMATOGRAPHY; RADIOCHEMICAL ANALYSIS; RESINS; TECHNETIUM 99
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMICAL ANALYSIS; CHROMATOGRAPHY; COMPLEXES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC POLYMERS; ORGANIC SULFUR COMPOUNDS; PETROCHEMICALS; PETROLEUM PRODUCTS; POLYMERS; QUANTITATIVE CHEMICAL ANALYSIS; RADIOISOTOPES; SEPARATION PROCESSES; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
12 refs., 1 fig., 3 tabs.