Evaluation of the clinical usefulness of 99mTc-HIgG scintigraphy for the abdominal inflammations

This study was to evaluate the efficiency and safety of 99mTc-HIgG as the tracer for detection of focal inflammatory lesions in abdomen. We have studied 57 in-patients (31 women and 26 men, mean age = 35 ± 15, range 20-49 yr) with 20 cases of pelvicellulitus, 30 cases of Inflammatory bowel diseases, 7 cases of abdominal abscess. All their diagnosis were based on clinical signs and various types of laboratory data and other imaging modalities. Scanning was performed at 1,2,4,6 hr delays or 24 hr if necessary after intravenous administration of 740 MBq of 99mTc-HIgG. 99mTc-HIgG was avidly taken up by acute pelvis inflammation lesions and performed less well in 2 chronic cases, so the positive rate was 90%. Of 30 cases IBD, 13 Crohn's disease, 17 ulcerative colitis, 12 patients with Crohn's disease at active stage were positive, 15 patients with ulcerative disease at active stage were positive, so the sensitivity was 92% and 88% respectively. There is no significant image in patients at relieve stage. Meanwhile they have good coincidence with the result of endoscopy and X-Rays. The sensitivity in 7 cases with pur in abdominal cavity was 100%. 99mTc-HIgG is proved to be effective in detecting focal site of inflammation in the abdomen. Provide clinically useful assessment of disease activity and reponse to therapy. Safe, convenient and no side effects. Physiological accumulation in some tissues such as the liver makes it difficult to localize