90Sr-90Y radionuclide generator based on ionex chromatography. Part 1 - project

This part contains a proposal for the generator column design, materials to be used (chemicals, ionexes) and technological procedures. The proposal was inspired by the 90Sr-90Y generator operated by Zfk Rossendorf. The aim was to develop and launch a generator for the preparation of carrier-free 90Y in the form of [90Y] chloride solution in dilute hydrochloric acid. The separation of Y from Sr is based on ionex chromatography by sorbing the two radionuclides on a catex. While Sr remains sorbed, 90Y is eluted with lithium citrate. During this process, 90Y is bonded in a citrate complex which, having a negative charge, is subsequently trapped by an anex. A guard column is inserted before the anex column to trap any traces of 90Sr. 90Y is eluted from the anex in the yttrium chloride form by using dilute hydrochloric acid. The product from the generator can be used for the preparation of [90Y] - Fe colloid injection or [90Y] - yttrium citrate injection for intra-articular application or for the development of monoclonal antibodies and peptides