Mucosal blood flow changes in the human stomach measured by the 99mTc-4-methylaminophenazone clearance technique

The effects of gastric secretory inhibitors, vasoactive agents and gastrointestinal peptide hormones were investigated on gastric mucosal blood flow (MBF) and HCl secretion in 197 subjects. Changes in MBF were estimated by a new clearance substance, 99mTc-4-methyl-aminophenazone originally described by the authors. The procedure seemed to be suitable for characterizing changes in MBF without any toxic side effect or considerable radioactive loading of the patient or his surroundings. Before starting the studies a secretory steady state was achieved by continuous pentagastrin infusion. The new technique proved to be reliable for screening drugs of vasoactive or secretion influencing properties. (author) 20 refs.; 14 figs.; 3 tabs