Serum soluble IL-2 receptor as a reliable and noninvasive marker of disease activity in patients with hairy cell leukemia
Creators
- 1. Department of Clinacal Hematology, University Hospital, Charles University, Faculty of Medicine, 500 05 Hradec Kralove (Czech Republic)
- 2. Institute of Pathology, University Hospital, Chahrles University, Faculty of Medicine, Hradec Kralove (Czech Republic)
- 3. Department of Medicine, Uniuversity Hospital, Charles University, Faculty of Medicine, Hradec Kralove (Czech Republic)
- 4. Institute of Clinical Biochemistry and Diagnostics, University Hospital, Charles University, Faculty of Medicine, Hradec Kralove (Czech Republic)
Description
Hairy cell leukemia is a chronic lymphoproliferative disorder of B-cell lineage. Malignant cells express the interleukin-2 receptor (IL-2R) which is released in vitro as well as in vivo. The sera of patients with hairy cell leukemia contain elevated levels of this soluble receptor (sIL-2R). Sere of 24 patients with hairy cell leukemia were tested for sIL-2R. In 9 patients treated with 2-chloro-deoxyadenosine an improved clinical status was associated with decreasing serum sIL-2R. The maximal rate of decrease of sIL-2R level was observed within the second and the third week after the therapy initiation. Patients with disease progression had an increase in serum sIL-2R level. Our results suggest that serial can be used as a reliable, noninvasive means to assess the disease activity and its response to therapy. (author)
Additional details
Publishing Information
- Journal Title
- Neoplasma
- Journal Volume
- 43
- Journal Issue
- 5
- Journal Page Range
- p. 321-325
- ISSN
- 0028-2685
INIS
- Country of Publication
- Slovakia
- Country of Input or Organization
- Slovakia
- INIS RN
- 29062614
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- ADENOSINE; ANTIBODIES; BIOMEDICAL RADIOGRAPHY; BLOOD SERUM; CAT SCANNING; DIAGNOSIS; ENZYME IMMUNOASSAY; EXPERIMENTAL DATA; IMMUNITY; INTERFERON; LEUKEMIA; LYMPHOCYTES; LYMPHOKINES; NUCLEAR MEDICINE; STATISTICAL DATA; THERAPY
- Descriptors DEC
- ANIMAL CELLS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BLOOD PLASMA; BODY FLUIDS; COMPUTERIZED TOMOGRAPHY; CONNECTIVE TISSUE CELLS; DATA; DIAGNOSTIC TECHNIQUES; DISEASES; IMMUNE SYSTEM DISEASES; IMMUNOASSAY; INFORMATION; LEUKOCYTES; MATERIALS; MEDICINE; NEOPLASMS; NUCLEOSIDES; NUCLEOTIDES; NUMERICAL DATA; ORGANIC COMPOUNDS; RIBOSIDES; SOMATIC CELLS; TOMOGRAPHY
Optional Information
- Notes
- 2 figs., 4 tabs., 15 refs.