Study on the standardization of the radioactivity measurement for 153Sm-EDTMP injection

The safety and efficacy of the therapeutic radiopharmaceuticals directly depends on its dosage. In order to determine the radioactivity of 153Sm-EDTMP injection accurately, and ensure the safety and efficacy of the 153Sm-EDTMP injection, the standardization for the radioactivity measurement of 153Sm-EDTMP injection with dose calibrators was studied, in which 4π liquid scintillator and 4πβ-γ coincidence method were used to determine the values of radioactivity (the relative expanded uncertainty is less than 3%)for the 153Sm-EDTMP injection standard source with six experimental setups in four laboratories, then the dose calibrators were calibrated with the standard source. The results showed that a the type of dose calibrator,the container and the volume of the sample solution have effects on the results of measurement, but between 3 to 5 mL, the variation of the volume of sample solution has little effect on the results of measurement. At last the measurement conditions were obtained according to the results of the study. (authors)