Preparation of glucoheptonate - sup(99m) Tc using stannous ascorbate as reducing agent for TcO-4 ion
Description
A preparation procedure of stannous ascorbate in lyophilized form is presented. This reducing agent was employed for the preparation of kits of calcium glucoheptonate (GHA) to be labelled with sup(99m) Tc for use in kidney scintigraphy. Comparative studies between kits prepared with stannous ascorbate and those prepared with stannous chloride as reducing agent were made. The labelling yield during 18 hours after the addition of sup(99m) TcO-4 was higher when stannous ascorbate was used. The stability of kits of calcium glucoheptonate - sup(99m) Tc containing stannous ascorbate was studied during five months after its preparation in the lyophilized form. On the fifth month the labelling yield of GHA - sup(99m) Tc was 89-95%, being therefore suitable for kidney scintigraphy. (Author)
Availability note (English)
MF available from INIS under the Report Number.Abstract (Portuguese)
Apresenta-se a preparacao do ascorbato estanoso na forma liofilizada. Esse agente redutor foi utilizado na preparacao de conjuntos de reativos de glucoheptonato de calcio (GHA) para marcacao com sup(99m) Tc e posterior uso em cintigrafia renal. Foram feitos estudos comparativos com conjuntos de reativos preparados com cloreto de estanho (II) como agente redutor. O rendimento de marcacao estudado durante 18 horas apos adicao de sup(99m) TcO-4 mostrou-se superior quando se usou o ascorbato estanoso. A estabilidade dos conjuntos de reativos de glucoheptonato de calcio - sup(99m) Tc que contem ascorbato estanoso foi analisada durante cinco meses apos a preparacao na forma liofilizada. No quinto mes, o rendimento de marcacao do GHA - sup(99m) Tc foi de 89-95% sendo, pois, adequado para uso em cintigrafia renal. (Autor)Files
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Additional details
Additional titles
- Original title (Portuguese)
- Preparacao do glucoheptonato - sup(99m) Tc utilizando ascorbato estanoso como redutor do ion TcO
Publishing Information
- Imprint Pagination
- 13 p.
- Report number
- IPEN-PUB--58
INIS
- Country of Publication
- Brazil
- Country of Input or Organization
- Brazil
- INIS RN
- 15066511
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ASCORBIC ACID; CHEMICAL PREPARATION; LABELLED COMPOUNDS; LYOPHILIZATION; REDUCING AGENTS; TECHNETIUM 99; TIN COMPOUNDS
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPES; SYNTHESIS; TECHNETIUM ISOTOPES; VITAMINS; YEARS LIVING RADIOISOTOPES