Published 1990
| Version v1
Report
Androgen receptor-based imaging agents for the prostate: Synthesis and tissue distribution studies with tritium and fluorine-18 labeled androgens
Creators
- 1. Univ. of Illinois, Urbana (United States)
- 2. Washington Univ., St. Louis, MO (United States)
Description
Prostatic tissue and most prostatic tumors contain receptors for androgens, so a suitable radiolabelled androgen could then act as an imaging agent for prostatic tumors. In order to develop suitable androgen-receptor based imaging agents, the authors first investigated the uptake of five androgens, available commercially in high specific activity tritium-labelled form, in the prostate of one-day castrated rats. Based on these uptake studies, they have synthesized 20-fluoromibolerone and have conducted tissue distribution studies in rats
Additional details
Publishing Information
- Imprint Title
- Eighth international symposium on radiopharmaceutical chemistry. Abstracts: Final report
- Imprint Pagination
- 458 p.
- Journal Page Range
- p. 445-448.
- Report number
- DOE/ER/60968--1
Conference
- Title
- 8. international symposium on radiopharmaceutical chemistry.
- Dates
- 24-29 Jun 1990.
- Place
- Princeton, NJ (United States).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 23029846
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference, Non-conventional Literature
- Descriptors DEI
- ACTIVITY LEVELS; ANDROGENS; CASTRATION; CHEMICAL PREPARATION; CHEMICAL REACTION KINETICS; DIAGNOSTIC TECHNIQUES; FLUORINE 18; LABELLING; MOLECULAR STRUCTURE; PROSTATE; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; RATS; RECEPTORS; TESTOSTERONE; TISSUE DISTRIBUTION; TRITIUM; UPTAKE
- Descriptors DEC
- ANDROSTANES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; DISTRIBUTION; DRUGS; FLUORINE ISOTOPES; GLANDS; HORMONES; HOURS LIVING RADIOISOTOPES; HYDROGEN ISOTOPES; HYDROXY COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KETONES; KINETICS; LABELLED COMPOUNDS; LIGHT NUCLEI; MALE GENITALS; MAMMALS; MATERIALS; MEDICINE; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; REACTION KINETICS; RODENTS; STEROID HORMONES; STEROIDS; SURGERY; SYNTHESIS; VERTEBRATES; YEARS LIVING RADIOISOTOPES
Optional Information
- Contract/Grant/Project number
- Contract FG02-86ER60401; FG02-84ER60218
- Secondary number(s)
- CONF-9006363--Absts.