Combined chemotherapy and radiotherapy: Cyclophosphamide

Compared to the other chemotherapeutic preparations discussed today, cyclophosphamide in combination with radiotherapy is a relatively unproblematic substance. Despite the great number of experimental and clinical data, the evaluation does not prove an advantage of the combined therapy with cyclophosphamide and irradiation as against radiotherapy alone in local tumor treatment. This should give occasion to further experimental investigations in adequate models. On the other hand, the practice of combined treatment with irradiation and preparations containing cyclophosphamide should be reconsidered for those cases where local control of a tumor is the principal therapeutic aim. (orig.)