Published November 1991 | Version v1
Journal article Metadata-only

3H-labelling of scopolamine and the labelling location

Creators

  • 1. China Inst. of Atomic Energy, Beijing (China)
  • 2. Dept. of Chemistry, Beijing Normal Univ. (China)

Description

Scopolamine is an important anesthetic. H-scopolamine was prepared by Wilzbach tritium gas-exposure method for the study of its pharmacokinetics. The total radioactivity of 3H-scopolamine was 61.8 MBq, radiochemical purity wa 97%, and specific activity was 3.9 MBq/mg. The location of 3H-labelling was studied by calculating the superdelocalizability Sr(E) by CNDO/2 method. The calculated results agreed with experimental values by chemical dissociation method. The calculations showed that 3H of tropic acid is 72% that of 3H-scopolamine. As can be seen, the location of 3H-labelling is mainly on the tropic acid

Additional details

Publishing Information

Journal Title
Journal of Isotopes
Journal Volume
4
Journal Issue
4
Journal Page Range
p. 221-225.
ISSN
1000-7512

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
24005006
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
ACTIVITY LEVELS; ALKALOIDS; CHEMICAL PREPARATION; LABELLING; PURIFICATION; RADIOPHARMACEUTICALS; TRITIUM
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DRUGS; HYDROGEN ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; YEARS LIVING RADIOISOTOPES