Published 1984 | Version v1
Book Metadata-only

Dose related changes in cell cycle of bone marrow and spleen cells monitored by DNA/RNA flow cytometry

Creators

  • 1. Gesellschaft fuer Strahlen-und Umweltforschung (GSF), Herrenhauserstr. 2, D-3000 Hannover 21

Description

Based on cell cycle analysis by flow cytometry on isolated mononuclear cells from bone marrow and spleen, dose-dependent alterations after radiation as well as after chemical treatment have been observed in C3H mice. Cells from the hemopoetic system are easily available and are ideally suited as biological endpoints for a biological dose determination in men. Such cells are also suitable for measurement of the additive or synergistic effect of two or more treatments at the same time. Based on computer analysis of two-parameter DNA/RNA measurements, alterations in the cell cycle kinetics can be monitored at as low as 80 rads whole-body radiation in mice

Additional details

Publishing Information

Publisher
Springer-Verlag New York Inc.
Imprint Place
New York, NY (USA)
ISBN
0-387-12790-9
Imprint Title
Biological dosimetry: Cytometric approaches to mammalian systems
Journal Page Range
p. 219-227.

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
19008253
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; BIOSYNTHESIS; BONE MARROW CELLS; CELL CYCLE; CELL FLOW SYSTEMS; CHEMOTHERAPY; DATA PROCESSING; DNA; DOSE-RESPONSE RELATIONSHIPS; DYNAMIC FUNCTION STUDIES; FORMALDEHYDE; IRRADIATION; MEN; MICE; ORAL ADMINISTRATION; RADIOSENSITIVITY; RADIOSENSITIZERS; RADIOTHERAPY; RNA; SPLEEN CELLS; WHOLE-BODY IRRADIATION
Descriptors DEC
ALDEHYDES; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; CONNECTIVE TISSUE CELLS; DRUGS; EXTERNAL IRRADIATION; INTAKE; MALES; MAMMALS; MAN; MEDICINE; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PRIMATES; RADIATION EFFECTS; RESPONSE MODIFYING FACTORS; RODENTS; SOMATIC CELLS; SYNTHESIS; THERAPY; VERTEBRATES