Treatment of 35 advanced oto-rhino-laryngological (ORL) tumors by two associations of simultaneous radiotherapy-chemotherapy

Two associations of radio-chemotherapy have been employed to treat ORL tumors. The first group received a classical treatment of radiotherapy with five time 1.8 Gy/week and 75 Gy in the whole with 3 cures of 4 days of Para platinum 60 mg/m2/day and 5 Fu 400 mg/m2/day with 3 weeks between each cure. The second group have been treated by a radiotherapy of 3 Gy 4 hours 3 Gy at D1,D3,D15,D17,D29,D31,D43 that is to say 48 Gy in 16 seances and 45 days with 3 days at each serie (D1 to D3,D15 to D17 and so on) and Cisplatin 15 mg/m2/day, 5 Fu 400 mg/m2/day, Hydrea (hydroxicarbamide) 1 g per Os/day, Vepeside (etoposide) 50 mg per Os/day and Pentoxifyllin 800 mg per Os/day and finally between the series, 1 injection of Velbe (vinblastine) 5 mg/m2, Thiotepa 5 mg/m2, 5 Fu 225 mg/m2. The cases of group II are more severe than the first one, at the end of irradiation a complete response is observed at the level of primary tumor for 67% of cases in the first group and 90% in the second one; the survive at one year is 40% in the group I and 43% in the group II. The radio sensitizing treatments have increased the rate of complete response and the immediate survive (at one year). The combination of the group II has been more efficient