Published March 2021 | Version v1
Journal article Metadata-only

The human aortic endothelium undergoes dose-dependent DNA methylation in response to transient hyperglycemia

Creators

  • 1. Institüt für Experimentelle Kardiologie, Universitätsklinikum Heidelberg, Heidelberg (Germany)
  • 2. Dept. of Biomedical Engineering, University of Alabama at Birmingham, Birmingham (United States)
  • 3. Dept. of Pathology, Division of Molecular & Cellular Pathology, University of Alabama at Birmingham, Birmingham (United States)
  • 4. Dept. of Advanced Medical and Surgical Sciences (DAMSS), Università Della Campania "Luigi Vanvitelli", P.za Miraglia, 2 - 80138, Naples (Italy)
  • 5. IRCCS SDN, Via E. Gianturco, 113 - 80143, Naples (Italy)
  • 6. Clinical Dept. of Internal Medicine and Specialistic Units, Università Della Campania "Luigi Vanvitelli", P.za Miraglia, 2 – 80138, Naples (Italy)
  • 7. Dept of Exercise and Wellness Sciences, University of Naples Parthenope, Via Ammiraglio Ferdinando Acton, 38 - 80133 Naples (Italy)

Description

Glycemic control is a strong predictor of long-term cardiovascular risk in patients with diabetes mellitus, and poor glycemic control influences long-term risk of cardiovascular disease even decades after optimal medical management. This phenomenon, termed glycemic memory, has been proposed to occur due to stable programs of cardiac and endothelial cell gene expression. This transcriptional remodeling has been shown to occur in the vascular endothelium through a yet undefined mechanism of cellular reprogramming.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.yexcr.2021.112485

Additional details

Identifiers

DOI
10.1016/j.yexcr.2021.112485;
PII
S0014482721000161;

Publishing Information

Journal Title
Experimental Cell Research
Journal Volume
400
Journal Issue
2
Journal Page Range
vp.
ISSN
0014-4827
CODEN
ECREAL

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
53118949
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
CARDIOVASCULAR DISEASES; DIABETES MELLITUS; DNA; ENDOTHELIUM; GENES; HEALTH HAZARDS; HYPERGLYCEMIA; METHYLATION; PATIENTS
Descriptors DEC
ANIMAL TISSUES; BODY; CHEMICAL REACTIONS; DISEASES; ENDOCRINE DISEASES; HAZARDS; METABOLIC DISEASES; NUCLEIC ACIDS; ORGANIC COMPOUNDS

Optional Information

Copyright
Copyright (c) 2021 Elsevier Inc. All rights reserved.