Published July 15, 1977 | Version v1
Journal article Metadata-only

Normal endonuclease activities for damaged DNA during hepatocarcinogenesis

Creators

  • 1. New York Univ., N.Y. (USA). Medical Center
  • 2. Anderson (M.D.) Hospital and Tumor Inst., Houston, Tex. (USA)

Description

Two endonuclease activities in rat liver for damaged DNA were assayed. Double-stranded, covalently closed DNA from phage PM2 was damaged by either ultraviolet irradiation or by heating at acid pH, and used as substrate for endonucleases specific for ultraviolet DNA damage and for DNA apurinic sites, respectively. The levels of both enzyme activities in livers of normal rats were compared to levels in livers of rats fed N-2-acetylaminofluorene. At critical stages of the carcinogenic regimen levels of both endonuclease activities were normal. This, together with other data, suggests that depression of excisionrepair of DNA damage does not take place during experimental carcinogenesis

Additional details

Identifiers

DOI
10.1016/0005-2787(77)90228-3;

Publishing Information

Journal Title
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis
Journal Volume
477
Journal Issue
2
Series
Biochim. Biophys. Acta - Nucl. Acids Protein Synth.
Journal Page Range
125-131
ISSN
0006-3002; 0005-2787

INIS

Country of Publication
Netherlands
Country of Input or Organization
Netherlands
INIS RN
8346825
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOASSAY; BIOCHEMICAL REACTION KINETICS; BIOLOGICAL REPAIR; CATALYSIS; DNA; EXPERIMENTAL NEOPLASMS; LIVER; NUCLEASES; RADIATION EFFECTS; STRAND BREAKS
Descriptors DEC
BIOLOGICAL RECOVERY; BODY; DIGESTIVE SYSTEM; DISEASES; ENZYMES; GLANDS; KINETICS; NEOPLASMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PERFORMANCE TESTING; PHOSPHOTRANSFERASES; REACTION KINETICS; TESTING; TRANSFERASES

Optional Information

Notes
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