Published 1981
| Version v1
Journal article
Interactions between X-rays and antimitotic drugs: cellular effects
Description
The interactions between three drugs and X-rays were examined in rat hepatoma cells in vitro. Incubation with Daunomycine or 9-hydroxy ellipticine decreases the survival of both exponential and plateau phase cells, whereas cis-Pt (II) decreases the survival of plateau cells, especially irradiated in anoxia. The decrease in the Do was greater when the cells were incubated with the drugs prior to X-irradiation, and was greater in the case of plateau cells than in the case of exponential cells. The repair of potentially lethal damages was inhibited by these three compounds. However, the repair of sublethal damages was inhibited by cis-Pt II, but was modified neither by Daunomycine nor 9-hydroxy ellipticine
Abstract (French)
L'influence de trois antimitotiques sur la survie des cellules traitees par les radiations ionisantes a ete mesuree in vitro. La Daunomycine et la 9-hydroxy ellipticine augmentent la radiosensibilite des cellules en phase exponentielle ou stationnaire, tandis que le cis-Pt (II) ne modifie que la survie des cellules stationnaires, en particulier irradiees en anoxie. La diminution de la Do est plus importante quand les cellules sont traitees par les drogues avant l'irradiation, et cette diminution est plus nette dans le cas des cellules stationnaires. La reparatition des lesions potentiellement letales est inhibee par les trois drogues etudiees, tandis que la reparation des lesions subletales est inhibee par le cis-Pt (II) mais n'est modifiee ni par Daunomycine ni par la 9-hydroxy ellipticineAdditional details
Additional titles
- Original title (French)
- Associations entre les radiations ionisantes et certains antimitotiques: effets au niveau cellulaire
Publishing Information
- Journal Title
- Bull. Cancer
- Journal Volume
- 68
- Journal Issue
- 2
- Series
- Bull. Cancer.
- Journal Page Range
- 116-120
- ISSN
- 0007-4551
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 13650181
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ANTIMITOTIC DRUGS; BIOLOGICAL REPAIR; IN VITRO; RADIOSENSITIVITY; RADIOTHERAPY; SURVIVAL CURVES; TUMOR CELLS; X RADIATION
- Descriptors DEC
- ANIMAL CELLS; BIOLOGICAL RECOVERY; DRUGS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MEDICINE; RADIATIONS; THERAPY