Published December 1993 | Version v1
Journal article Metadata-only

Compromising effect of low dose-rate total body irradiation on allogeneic bone marrow engraftment

Creators

  • 1. Groningen Univ. (Netherlands). Dept. of Radiobiology

Description

The protraction of total body irradiation (TBI) to a continuous low dose-rate (LDR) has been investigated for its effect on donor marrow engraftment in murine bone marrow transplant (BMT) models of varying histocompatibility. The data suggest that radiation damage repair during LDR irradiation in an immunocyte target cell population is mainly responsible for enhanced graft rejection thus rendering protracted TBI less effective for application in clinical allogeneic BMT. (Author)

Additional details

Publishing Information

Journal Title
International Journal of Radiation Biology
Journal Volume
64
Journal Issue
6
Journal Page Range
p. 761-770.
ISSN
0955-3002
CODEN
IJRBE7

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
25025229
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BONE MARROW; DNA REPAIR; GRAFT-HOST REACTION; LOW DOSE IRRADIATION; MICE; TRANSPLANTS; WHOLE-BODY IRRADIATION
Descriptors DEC
ANIMALS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; BODY; EXTERNAL IRRADIATION; HEMATOPOIETIC SYSTEM; IRRADIATION; MAMMALS; ORGANS; RODENTS; TISSUES; VERTEBRATES