Biological-clinical study of radiosensitivity and chemosensitivity of squamous cell carcinoma of the mouth. Growth and regression rates, dynamic histology, and cell kinetics

Effects of combined methotrexate and radiotherapy were studied in 22 patients with advanced squamous cell cancer of the upper air passages. Studies included clinical growth rate of tumor volume prior to treatment, cell kinetics before treatment, electron microscope studies of serial biopsies, response of tumor to methotrexate and radiation, and time and rate of recurrences. Case histories are described for four different types of tumors and results are discussed. (U.S.)