Published March 2012 | Version v1
Journal article Metadata-only

Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s

Creators

  • 1. Centre for Plasma Physics, Queen's University Belfast, BT7 1NN (United Kingdom)
  • 2. School of Physics and Astronomy, University of Birmingham, B15 2TT (United Kingdom)
  • 3. Hall Edwards Radiotherapy Research Group, Dept. of Medical Physics, University Hospital Birmingham, B15 2TH (United Kingdom)
  • 4. Ion Beam Centre, Advanced Technology Institute, University of Surrey, Guildford GU2 7XH (United Kingdom)
  • 5. Centre for Cancer Research and Cell Biology, Queen's University Belfast, BT9 7BL (United Kingdom)

Description

The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

Additional details

Identifiers

DOI
10.1063/1.3699063;

Publishing Information

Journal Title
AIP Advances
Journal Volume
2
Journal Issue
1
Journal Page Range
p. 011209-011209.6
ISSN
2158-3226
CODEN
AAIDBI

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
44023141
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; COMPARATIVE EVALUATIONS; DOSE RATES; IRRADIATION; KEV RANGE 100-1000; LASER RADIATION; LASERS; MEV RANGE; PROTONS; RBE; X RADIATION
Descriptors DEC
BARYONS; BIOLOGICAL EFFECTS; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; ENERGY RANGE; EVALUATION; FERMIONS; HADRONS; IONIZING RADIATIONS; KEV RANGE; NUCLEONS; RADIATION EFFECTS; RADIATIONS