Published April 2005
| Version v1
Journal article
Production of [17F]CH3F (t1/2=65s), an improved PET tracer for rCBF measurement
Creators
- 1. Medical Physics, University of Wisconsin, 1500 N. Highland Ave. T-121 Waisman Center, Madison, WI 53705 (United States)
- 2. Manchester Molecular Imaging Center, University of Manchester, M20 3LJ (United Kingdom)
Description
Production of 17F (t1/2=65s) in the form of [17F] F2 has been achieved using both the 20Ne(p,α)17F and 16O(d,n)17F reactions with 11MeV protons and 6MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [17F]CH3F (>60mCi in saline), currently in use for fast repetition human studies of regional cerebral blood flow with positron emission tomography. Thick target yields of 15mCi/μA for protons and 44mCi/μA for deuterons have been measured for [17F]F2
Additional details
Identifiers
- DOI
- 10.1016/j.apradiso.2004.08.044;
- PII
- S0969-8043(04)00492-0;
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 62
- Journal Issue
- 4
- Journal Page Range
- p. 525-532
- ISSN
- 0969-8043
- CODEN
- ARISEF
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 36063855
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- BLOOD FLOW; DEUTERON REACTIONS; DEUTERONS; FLUORINE 17; METHYL FLUORIDE; MEV RANGE 01-10; MEV RANGE 10-100; NEON 20 TARGET; OXYGEN 16 TARGET; POSITRON COMPUTED TOMOGRAPHY; PROTON REACTIONS; PROTONS; RADIOPHARMACEUTICALS
- Descriptors DEC
- BARYON REACTIONS; BARYONS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHARGED PARTICLES; CHARGED-PARTICLE REACTIONS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; ELEMENTARY PARTICLES; EMISSION COMPUTED TOMOGRAPHY; ENERGY RANGE; FERMIONS; FLUORINATED ALIPHATIC HYDROCARBONS; FLUORINE ISOTOPES; HADRON REACTIONS; HADRONS; HALOGENATED ALIPHATIC HYDROCARBONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MEV RANGE; MINUTES LIVING RADIOISOTOPES; NUCLEAR REACTIONS; NUCLEI; NUCLEON REACTIONS; NUCLEONS; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; TARGETS; TOMOGRAPHY
Optional Information
- Copyright
- Copyright (c) 2004 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.