Published October 2019 | Version v1
Journal article Metadata-only

Validation of the dicentric chromosome assay for radiation biological dosimetry in South Korea

Creators

  • 1. Laboratory of Biological Dosimetry, National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of (Korea, Republic of)
  • 2. National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of (Korea, Republic of)
  • 3. Consumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Ontario (Canada)

Description

The dicentric chromosome assay (DCA) is a well-established biodosimetry test to estimate exposure to ionizing radiation. The Korea Institute of Radiological and Medical Sciences (KIRAMS) established a DCA protocol as a medical response to radiation emergencies in South Korea. To maintain its accuracy and performance, intercomparison exercises with Health Canada (HC) have been conducted; herein, we aimed to validate our capacity of DCA analysis based on those results. Blood samples irradiated at HC were shipped to KIRAMS to assess the irradiation dose to blinded samples using conventional DCA full scoring and triage-based techniques (conventional DCA scoring in triage mode and DCA QuickScan method). Actual doses fell within the 95% confidence intervals of dose estimates for 70-100% of the blinded samples in 2015-2018. All methods discriminated binary dose categories, reflecting clinical significance. This DCA can be used as a reliable radiation biodosimetry tool in preparation for radiation accidents in South Korea.

Availability note (English)

Available from http://dx.doi.org/10.1093/jrr/rrz039; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806015

Additional details

Identifiers

URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806015; http://creativecommons.org/licenses/by-nc/4.0/;
DOI
10.1093/jrr/rrz039;

Publishing Information

Journal Title
Journal of Radiation Research
Journal Volume
60
Journal Issue
5
Journal Page Range
p. 555-563
ISSN
0449-3060

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
54118597
Subject category
S61: RADIATION PROTECTION AND DOSIMETRY;
Descriptors DEI
ACCURACY; BIOASSAY; BLOOD; DICENTRIC CHROMOSOMES; DOSIMETRY; EMERGENCY PLANS; GY RANGE 01-10; MICRO GY RANGE 100-1000; RADIATION ACCIDENTS; RADIATION INJURIES; RADIATION PROTECTION; REPUBLIC OF KOREA
Descriptors DEC
ABSORBED DOSE RANGE; ACCIDENTS; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BODY FLUIDS; CHROMOSOMES; DEVELOPING COUNTRIES; DISEASES; GY RANGE; INJURIES; MATERIALS; MICRO GY RANGE; RADIATION DOSE RANGES; RADIATION EFFECTS

Optional Information

Copyright
Copyright (c) The Author(s) 2019. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.
Notes
PMCID: PMC6806015; PMID: 31165147; PMID: 31165147; PUBLISHER-ID: rrz039; OAI: oai:pubmedcentral.nih.gov:6806015