Published October 1989 | Version v1
Journal article Metadata-only

Metabolic fate of L-[methyl-11C]methionine in human plasma

Creators

  • 1. Tohoku Univ., Sendai (Japan). Div. of Radiopharmaceutical Chemistry
  • 2. Tohoku Univ., Sendai (Japan). Div. of Nuclear Medicine
  • 3. Tohoku Univ., Sendai (Japan). Dept. of Radiology and Nuclear Medicine
  • 4. Tohoku Univ., Sendai (Japan). Div. of Neurosurgery

Description

The metabolites of L-[methyl-11C]methionine in the plasma of 8 patients with tumor were measured for 60 min after injection. In the plasma, after a rapid clearance, the total radioactivity remained constant, and protein-bound radioactivity increased rapidly. Non protein metabolites detected by HPLC as at least two components besides methionine, increased with time. Significant individual variations for the metabolism were observed. At 60 min after injection, 36.5% (range: 16%-72%) and 45.3% (range: 13%-74%) of the 11C was measured as methionine and labeled proteins, respectively. (orig.)

Additional details

Publishing Information

Journal Title
European Journal of Nuclear Medicine
Journal Volume
15
Journal Issue
10
Series
Eur. J. Nucl. Med.
Journal Page Range
665-669
ISSN
0340-6997
CODEN
EJNMD

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
20075860
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BLOOD PLASMA; CARBON 11; INJECTION; LABELLED COMPOUNDS; MAN; METABOLISM; METHIONINE; PROTEINS; TRACER TECHNIQUES
Descriptors DEC
AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BODY FLUIDS; CARBON ISOTOPES; CARBOXYLIC ACIDS; DRUGS; EVEN-ODD NUCLEI; INTAKE; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; LIPOTROPIC FACTORS; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PRIMATES; RADIOISOTOPES; VERTEBRATES