Published January 2010 | Version v1
Journal article Metadata-only

Involvement of substance P and the neurokinin-1 receptor in radiation-induced hair loss in mice

Creators

  • 1. Osaka Univ., Graduate School of Medicine, Suita, Osaka (Japan)
  • 2. Osaka Univ., Inst. of Scientific and Industrial Research, Ibaraki, Osaka (Japan)

Description

We investigated the involvement of substance P (SP) and the neurokinin-1 receptor (NK1R) in the development of radiation-induced hair loss in mice. A dose of 40 Gy of gamma irradiation induced hair loss from the 10th to at least the 60th day after irradiation. A specific NK1R antagonist, CP-99,994, significantly delayed radiation-induced hair loss and reduced its severity. Furthermore, gamma irradiation induced the expression of preprotachykinin-A, a precursor protein of SP, mRNA in irradiated murine skin on the 10th and 30th days after irradiation. These results indicated that gamma irradiation-induced hair loss was mediated by SP via NK1R. (author)

Availability note (English)

Available from http://dx.doi.org/10.1254/jphs.09256SC

Additional details

Identifiers

DOI
10.1254/jphs.09256SC;

Publishing Information

Journal Title
Journal of Pharmacological Sciences
Journal Volume
112
Journal Issue
1
Journal Page Range
p. 118-120
ISSN
1347-8613

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
41095803
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
COBALT 60; FRACTIONATED IRRADIATION; GAMMA RADIATION; GENETIC RADIATION EFFECTS; HAIR; LOSSES; MICE; RADIATION DOSES; RECEPTORS
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; COBALT ISOTOPES; DOSES; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MEMBRANE PROTEINS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; SKIN; VERTEBRATES; YEARS LIVING RADIOISOTOPES