The effect of cystamine on tissue sulfhydryl substances in rats
Creators
- 1. Karlova Universita, Hradec Kralove (Czechoslovakia). Lekarska Fakulta
Description
The concentrations of total and non-protein SH-substances were determined spectrophotometrically in liver, spleen, kidney, intestine and bone marrow of male rats after i.p. administration of cystamine (20 and 50 mg/kg) at four time intervals (10 - 60 min). After administration of an ineffective dose of 20 mg/kg an increase especially in non-protein SH-substances was found (maximum - 10 min after administration). However, there were no changes in the bone marrow. The optimum protective dose of 50 mg/kg caused a significant increase in total and non-protein thiols in radiosensitive tissue and in the kidney. The radioprotective effect seems to be based on an increase in non-protein SH-substances during the period of the highest protective effect. (author)
Additional details
Publishing Information
- Journal Title
- Radiobiol. Radiother.
- Journal Volume
- 19
- Journal Issue
- 3
- Series
- Radiobiol. Radiother.
- Journal Page Range
- 317-324
- ISSN
- 0033-8184
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- German Democratic Republic
- INIS RN
- 9404687
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BONE MARROW; CYSTAMINE; INTESTINES; KIDNEYS; LIVER; QUANTITY RATIO; RADIATION PROTECTION; RATS; SPECTROPHOTOMETRY; SPLEEN; THIOLS
- Descriptors DEC
- AMINES; ANIMALS; BODY; DIGESTIVE SYSTEM; DRUGS; GASTROINTESTINAL TRACT; GLANDS; HEMATOPOIETIC SYSTEM; MAMMALS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; TISSUES; VERTEBRATES