Experience with ^99mTc-tektrotyd in the diagnosis of ectopic localization of acth-secreting tumors in patients with cushings syndrome

The differential diagnosis of Cushings disease is often carried out with Cushings syndrome, caused by the presence of tumors producing bioactive ACTH or ACTH-like substance. The aim of the study was to determine the effectiveness of the use of scintigraphy with ^99mTc-Tektrotyd in the diagnosis of ectopic localization of ACTH-secreting tumors in patients with Cushings syndrome. The survey of 25 patients with elevated levels of ACTH in the peripheral blood, allowed in 10 (40 %) patients identify foci of increased uptake radiopharmaceutical analog of somatostatin. It was found that the scintigraphy ^99mTc-Tektrotyd is sensitive and specific method in determining the foci of ectopic ACTH production. The use of scintigraphy with ^99mTc-Tektrotyd may be a good alternative to studies with octreotide labeled with ^1UIn or ¹²³I in the diagnosis of ectopic ACTH syndrome due to lower radiation dose to the patient, the higher picture quality and greater availability of this radiopharmaceutical