Published September 1982 | Version v1
Journal article Metadata-only

The deuteration of acetanilides

Creators

  • 1. Warwick Univ., Coventry (UK). Dept. of Chemistry and Molecular Sciences

Description

The base-catalysed exchange of a proton of the methyl groups in acetanilides can be used to incorporate deuterium into these amides. 4'-Hydroxyl-2[2H]acetanilide (acetaminophen, paracetamol) can be prepared by the demethylation with boron tribromide of 4'-methoxy-2[2H] acetamide obtained by this base-catalysed exchange. (author)

Additional details

Publishing Information

Journal Title
J. Labelled Compd. Radiopharm.
Journal Volume
19
Journal Issue
9
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
1057-1061

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
14736334
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
ACETIC ACID; AMIDES; ANALGESICS; CATALYSIS; CHEMICAL PREPARATION; DEUTERATION; DEUTERIUM; HEAVY WATER; ISOTOPIC EXCHANGE; LABELLED COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; PIPERIDINES
Descriptors DEC
AMINES; AZINES; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; DRUGS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; MONOCARBOXYLIC ACIDS; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXYGEN COMPOUNDS; PYRIDINES; STABLE ISOTOPES; SYNTHESIS; WATER