Published June 2011 | Version v1
Journal article Metadata-only

Study on radioprotective effect of oligo-chitosan on the spleen of animals

Creators

  • 1. China Institute for Radiation Protection, Taiyuan (China)

Description

Objective: To study the radioprotective effect of splee of oligo-chitosan for mice injured by 60Co irradiation. Methods: Using 60Co γ-ray irradiation mice, the influence of oligo-chitosan on index of splee, apoptpsis genes of bcl-2, bax, caspse-3 and protein of P53, Gadd 45 were observed. Results: The results showed Oligo-chitosan increased the indexes of spleen, inhibited the genes of Bax, caspas-3 transfected and increased the gene of Bcl-2 expression, and elevated protein expression of P53 and Gadd45, compared with irradiation control. Conclusion: Oligo-chitosan could reduce the injury by radiation and protect spleen of irradiated mice. (authors)

Additional details

Publishing Information

Journal Title
Chinese Journal of Radiological Health
Journal Volume
20
Journal Issue
2
Journal Page Range
p. 156-158
ISSN
1004-714X

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
43084800
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
AMINO ACIDS; CHITIN; COBALT 60; GAMMA RADIATION; GENES; INHIBITION; IRRADIATION; MICE; OLIGOSACCHARIDES; PROTEINS; RADIATION INJURIES; RADIATION PROTECTION; RADIOPROTECTIVE SUBSTANCES; SPLEEN
Descriptors DEC
AMINES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARBOHYDRATES; CARBOXYLIC ACIDS; COBALT ISOTOPES; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; INJURIES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; MUCOPOLYSACCHARIDES; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; POLYSACCHARIDES; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RESPONSE MODIFYING FACTORS; RODENTS; SACCHARIDES; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
3 figs., 3 tabs., 5 refs.