Published March 1985 | Version v1
Journal article Metadata-only

Comparison of the tumor-seeking agent Tc-99m(V) dimercaptosuccinic acid and the renal imaging agent Tc-99m dimercaptosuccinic acid in humans

Creators

  • 1. Kobe Tamatsu Hospital, Japan

Description

Being aware of the ideal nuclear properties of Tc-99m, interest has been focused on the design of the (+5) oxidation state Tc-99m(V) dimercaptosuccinic acid (Tc(V)-DMSA) as a tumor-seeking agent. Tc-99m(V) DMSA holds a TcO4(3-) core and, like PO4(3-), has excellent characteristics for tumor uptake, but has a different distribution than the well-known renal scanning agent, Tc-99m DMSA. The differences in chemical behavior of Tc-99m(V) DMSA and Tc-99m DMSA are discussed. Three cases in which neoplasms were studied with Tc-99m(V) DMSA and Tc-99m DMSA are presented. Tc-99m DMSA and Tc-99m(V) DMSA, having a common ligand and tracer but, with the metal ion core in a different oxidation state, the uptake characteristics are altered markedly

Additional details

Publishing Information

Journal Title
Clin. Nucl. Med.
Journal Issue
no.3
Series
Clin. Nucl. Med.
ISSN
0363-9762
CODEN
CNMED

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
17016845
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
COMPARATIVE EVALUATIONS; DISTRIBUTION; ISOMERIC NUCLEI; KIDNEYS; LIGANDS; NEOPLASMS; SUCCINIC ACID; TECHNETIUM 99; TISSUES; TRACER TECHNIQUES
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; DICARBOXYLIC ACIDS; DISEASES; EVALUATION; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES