Radionuclide kinetics in MIRD dose calculations

A recent case report is reviewed and an alternative model for the radionuclide kinetics is presented; it estimates in an absorbed dose differing by a factor of two from the published calculation. Both models are consistent with observed data. Within a compartment model, one may choose to monitor a compartment of interest directly, or to monitor another compartment and (indirectly) solve for the activity in the compartment of interest. Advantages and disadvantages are reviewed