Published September 2011 | Version v1
Journal article Metadata-only

A 'green' synthesis of N-(quinoline-3-ylmethylene)benzohydrazide derivatives and their cytotoxicity activities

Creators

  • 1. Center for Chemical Sciences and Technology and Center for Biotechnology, Institute for Sciences and Technology, JNT University, Kukatpally, Hyderabad (India)
  • 2. Department of Chemistry, MNR Degree and PG College, Kukatpally, Hyderabad (India)
  • 3. Center for Biotechnology, Institute for Sciences and Technology, JNT University, Kukatpally, Hyderabad (India)

Description

We report some hybrid molecules based on N-(quinoline-3-ylmethylene)benzohydrazide template the synthesis of which was carried out using 2-chloroquinoline-3-carbaldehyde and a variety of substituted hydrazides in PEG 400. The 'green' solvent PEG 400 was recovered and reused for several times in the present reaction and was found to be effective in terms of product yield. Some of the compounds synthesized showed significant cytotoxic activity when tested in vitro. (author)

Availability note (English)

Available from http://www.scielo.br/pdf/jbchs/v22n9/v22n9a17.pdf

Additional details

Identifiers

URL
http://www.scielo.br/pdf/jbchs/v22n9/v22n9a17.pdf;

Publishing Information

Journal Title
Journal of the Brazilian Chemical Society
Journal Volume
22
Journal Issue
9
Journal Page Range
p. 1742-1749
ISSN
0103-5053
CODEN
JOCSET

INIS

Country of Publication
Brazil
Country of Input or Organization
Brazil
INIS RN
43043608
Subject category
S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
Descriptors DEI
CARBON 13; DIOXANE; DMSO; GLUTAMINE; HYDRAZIDES; HYDROGEN 1; INFRARED SPECTRA; METHYLENE RADICALS; NMR SPECTRA; QUINOLINES; TOXICITY
Descriptors DEC
AMIDES; AMINO ACIDS; AROMATICS; AZAARENES; AZINES; CARBON ISOTOPES; CARBOXYLIC ACIDS; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PYRIDINES; RADICALS; SPECTRA; STABLE ISOTOPES; SULFOXIDES