Published February 2016 | Version v1
Journal article Metadata-only

Design and radio-synthesis of somatostatin receptors targeted 68Ga-DOTA-Benereotide for non-invasive PET imaging

Creators

  • 1. Peking University Cancer Hospital and Institute, Beijing (China). Key Laboratory of Carcinogenesis and Translational Research, Department of Nuclear Medicine
  • 2. Hebei North University, Zhangjiakou (China). Department of Radiology, First Affiliated Hospital
  • 3. The University of Texas MD Anderson Cancer Center, Houston, TX (United States). Department of Cancer Systems Imaging

Description

Here we reported the synthesis, radiolabeling and evaluation of a novel positron emission tomography (PET) tracer DOTA-Benerotide labeled with 68Ga with potential application in SSTR1,2,3,5 positive tumors for PET imaging. Radiolabeling of DOTA-Benerotide with 68Ga achieved its highest efficiency at pH 3.5 and 100 deg C for 20 min. It also showed excellent in vitro stability in different buffers. Micro-PET imaging of human colorectal adenocarcinoma tumor cell (HT-29) bearing mice clearly delineated tumors at 4 h after tail vein injection of 68Ga-DOTA-Benerotide tracer. Further studies are needed to identify the mechanism of cell/organ uptake of this new SSTR PET imaging tracer. (author)

Additional details

Publishing Information

Journal Title
Journal of Radioanalytical and Nuclear Chemistry
Journal Volume
307
Journal Issue
2
Journal Page Range
p. 1069-1075
ISSN
0236-5731
CODEN
JRNCDM

INIS

Country of Publication
Hungary
Country of Input or Organization
Hungary
INIS RN
47015303
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
CARCINOMAS; DRUGS; GALLIUM 68; IN VITRO; LABELLED COMPOUNDS; LARGE INTESTINE; PH VALUE; POSITRON COMPUTED TOMOGRAPHY; SYNTHESIS; TEMPERATURE DEPENDENCE; TISSUE DISTRIBUTION; TRACER TECHNIQUES; TRANSGENIC MICE
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; GALLIUM ISOTOPES; GASTROINTESTINAL TRACT; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTESTINES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MICE; NEOPLASMS; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; RODENTS; TOMOGRAPHY; TRANSGENIC ANIMALS; VERTEBRATES

Optional Information

Notes
21 refs.