Published April 1990
| Version v1
Journal article
The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome
- 1. Johns Hopkins Univ. School of Medicine, Baltimore, MD (USA)
Description
To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, the authors hypothesize that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. Analysis of the 3' ends of three specific Alu sequences showed two occurrences, one in the adenosine deaminase gene and other in the β-globin pseudogene, were polymorphic. This novel class of polymorphism, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome
Additional details
Publishing Information
- Journal Title
- Proceedings of the National Academy of Sciences of the United States of America
- Journal Volume
- 87
- Journal Issue
- 7
- Series
- Proc. Natl. Acad. Sci. U.S.A.
- Journal Page Range
- 2951-2954
- ISSN
- 0027-8424
- CODEN
- PNASA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 22034122
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- BIOLOGICAL MARKERS; CHROMOSOMES; DNA SEQUENCING; GENE REGULATION; GLOBINS; LYASES; MAN; PHOSPHORUS 32
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; ENZYMES; ISOTOPES; LIGHT NUCLEI; MAMMALS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PHOSPHORUS ISOTOPES; PRIMATES; PROTEINS; RADIOISOTOPES; STRUCTURAL CHEMICAL ANALYSIS; VERTEBRATES