Alterations of transforming growth factor-α level in patients with liver disease
Creators
- 1. Second Affiliated Hospital of Guangzhou Medical College, Guangzhou (China)
Description
The author is to observe the changes of serum transforming growth factor-α (TGF-α) by RIA in 212 patients with various liver diseases and 88 healthy subjects. The results showed that serum TGF-α levels of patients with acute hepatitis (AH), chronic hepatitis grave (CHG), hepatocirrhosis (HC) and hepatocellular carcinoma (HCC) were higher than that of the normal controls (P < 0.001-< 0.01). There was no difference in serum TGF-α levels of the normal controls and patients with chronic hepatitis light (CHI). The levels of serum TGF-α were positively correlated with TBIL and ALT in patients with AH, CHG and CHL. The results suggest that the TGF-α may play an important role in processes of inflammatory injury, repair, fibrosis and the induction of hepatic tumour proliferation in patients with hepatitis
Additional details
Publishing Information
- Journal Title
- Labeled Immunoassays and Clinical Medicine
- Journal Volume
- 8
- Journal Issue
- 3
- Journal Page Range
- p. 127-129
- ISSN
- 1006-1703
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 33015602
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BILIRUBIN; BLOOD SERUM; DIAGNOSIS; ENZYMES; HEPATITIS; HEPATOMAS; LIVER CIRRHOSIS; MEDICAL EXAMINATIONS; PATENTS; POLYPEPTIDES; PROTEINS; RADIOIMMUNOASSAY
- Descriptors DEC
- AZOLES; BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY FLUIDS; CARBOXYLIC ACIDS; CARCINOMAS; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM DISEASES; DISEASES; DOCUMENT TYPES; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; IMMUNOASSAY; ISOTOPE APPLICATIONS; MATERIALS; MEDICAL SURVEILLANCE; NEOPLASMS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PEPTIDES; PIGMENTS; PROTEINS; PYRROLES; RADIOASSAY; RADIOIMMUNODETECTION; TRACER TECHNIQUES