The impact of ultra-early embolization treatment for ruptured intracranial aneurysms on patient's prognosis

Objective: To discuss the impact of ultra-early embolization treatment on clinical outcome in patients with ruptured intracranial aneurysms. Methods: A total of 270 patients with ruptured intracranial aneurysms were enrolled in this study. According the time to perform embolization with coils the patients were divided into group A (coiling being performed within 24 hours after the onset of rupture, n = 135) and group B (coiling being performed 24 hours after the onset of rupture, n = 135). The effect of ultra-early coiling embolization on clinical outcome was analyzed by using univariate analysis and multivariate logistic regression analysis. Results: The patients of group A and group B had the similar clinical and imaging features at the time of admission. Six months after the treatment, good results (mRS 0-2) were obtained in 122 cases (90.4%) of group A and in 110 cases (81.5%) of group B. The difference in prognosis between the two groups was statistically significant (P = 0.036). Multivariate logistic regression analysis showed that ultra-early embolization with coils (P = 0.021; OR, 2.536; 95%CI, 1.637-5.116) was an independent predictor indicating a better clinical outcome (mRS 0-2). Conclusion: Ultra-early (within 24 hours after the onset of rupture) coiling can improve clinical outcome in patients with ruptured intracranial aneurysms. (authors)