Published 1985 | Version v1
Journal article Metadata-only

Decrease of radioresistance and general resistance in altitude-adapted rats

Creators

  • 1. Kazakhskij Nauchno-Issledovatel'skij Inst. Onkologii i Radiologii, Alma-Ata (USSR)

Description

Rats adapted during 21 and 120 days, resp., to chronical moderate hypoxy (3340 m above sea level) were lowered from the mountains to the altitude of 847 m above sea level and 1 - 2 hours later 137Cs γ-irradiated with doses of 7.4, 8.4 and 9.7 Gy. There was an essential decrease of radioresistance in adapted animals as compared to non-adapted ones. The factor of dose change at the level of the mean lethal dose was 1.19. Injection of the biologically active polysaccharide prodigiozane in therapeutical doses to adapted rats produced a toxic effect. Decrease of radioresistance is due to hyperoxy. (author)

Additional details

Additional titles

Original title (German)
Verminderung der Radioresistenz und der allgemeinen Widerstandsfaehigkeit bei Ratten in der Initialperiode der postalpinen Readaptation

Publishing Information

Journal Title
Radiobiol. Radiother.
Journal Volume
26
Journal Issue
6
Series
Radiobiol. Radiother.
Journal Page Range
807-812
ISSN
0033-8184
CODEN
RDBGA

INIS

Country of Publication
Germany
Country of Input or Organization
German Democratic Republic
INIS RN
17012476
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ACCLIMATION; ANOXIA; BIOLOGICAL RADIATION EFFECTS; CESIUM 137; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; LETHAL IRRADIATION; POLYSACCHARIDES; RADIOSENSITIVITY; RATS; RESPONSE MODIFYING FACTORS; SURVIVAL CURVES
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; CARBOHYDRATES; CESIUM ISOTOPES; ELECTROMAGNETIC RADIATION; INTERMEDIATE MASS NUCLEI; IONIZING RADIATIONS; IRRADIATION; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; SACCHARIDES; VERTEBRATES; YEARS LIVING RADIOISOTOPES