Published November 16, 2015 | Version v1
Journal article Metadata-only

Electronic transport in methylated fragments of DNA

Creators

  • 1. Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte, 59072-970 Natal-RN (Brazil)
  • 2. Departamento de Física, Universidade Federal do Ceará, 60455-760 Fortaleza, CE (Brazil)
  • 3. Instituto Federal de Educação, Ciência e Tecnologia do Ceará, 60040-531 Fortaleza, CE (Brazil)
  • 4. Instituto de Física, Universidade Federal de Alagoas, 57072-900 Maceió-AL (Brazil)

Description

We investigate the electronic transport properties of methylated deoxyribonucleic-acid (DNA) strands, a biological system in which methyl groups are added to DNA (a major epigenetic modification in gene expression), sandwiched between two metallic platinum electrodes. Our theoretical simulations apply an effective Hamiltonian based on a tight-binding model to obtain current-voltage curves related to the non-methylated/methylated DNA strands. The results suggest potential applications in the development of novel biosensors for molecular diagnostics

Additional details

Identifiers

DOI
10.1063/1.4936099;

Publishing Information

Journal Title
Applied Physics Letters
Journal Volume
107
Journal Issue
20
Journal Page Range
p. 203701-203701.4
ISSN
0003-6951
CODEN
APPLAB

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
47056091
Subject category
S71: CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS;
Descriptors DEI
DNA; ELECTRIC CONDUCTIVITY; ELECTRODES; GENES; HAMILTONIANS; MODIFICATIONS; PLATINUM; SIMULATION
Descriptors DEC
ELECTRICAL PROPERTIES; ELEMENTS; MATHEMATICAL OPERATORS; METALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PHYSICAL PROPERTIES; PLATINUM METALS; QUANTUM OPERATORS; TRANSITION ELEMENTS

Optional Information

Notes
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