Published August 2007 | Version v1
Journal article Metadata-only

Distribution of 131I-labeled recombinant human erythropoietin in maternal and fetal organs following intravenous administration in pregnant rats

Creators

  • 1. Dokuz Eylul University, Izmir (Turkey). School of Medicine, Department of Animal Research Center
  • 2. Ege University, Izmir (Turkey). Institute of Nuclear Sciences, Department of Nuclear Applications
  • 3. Dokuz Eylul University, Izmir (Turkey). School of Medicine, Department of Anesthesiology and Reanimation
  • 4. Dokuz Eylul University, Izmir (Turkey). School of Medicine, Department of Neurosurgery

Description

The aim of the present study was to demonstrate the possible transplacental transmission of 131I labeled recombinant human erythropoietin (131I-rh-EPO) in pregnant rats and its distribution through maternal and fetal organs. Six Wistar Albino Rats in their pregnancy of 18 days were used 131I labeled recombinant human erythropoietin (specific activity = 2.4 μCi/IU) was injected into the tail vein of rats. After 30 minutes labeled erythropoietin infusion maternal stomach, kidney, lung, liver, brain and heart as well as fetus were removed. Then, the same organs were removed from each fetus. Measuring weight of maternal and fetal organs as well as placenta were followed by radioactivity count via Cd(Te) detector. 131I labeled recombinant human erythropoietin was found to be able to pass rat placenta and its distribution order in fetal organs was similar to those of maternal organs. Besides, as measurements were performed closer to cornu uteri, uptakes were decreasing in every fetus and its corresponding placenta. (author)

Additional details

Publishing Information

Journal Title
Journal of Radioanalytical and Nuclear Chemistry
Journal Volume
273
Journal Issue
2
Journal Page Range
p. 311-313
ISSN
0236-5731
CODEN
JRNCDM

INIS

Country of Publication
Hungary
Country of Input or Organization
Hungary
INIS RN
38105991
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ERYTHROPOIETIN; FETUSES; INTRAVENOUS INJECTION; IODINE 131; LABELLED COMPOUNDS; PLACENTA; PREGNANCY; RATS; SPATIAL DISTRIBUTION
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; FETAL MEMBRANES; HORMONES; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MAMMALS; MEMBRANES; MITOGENS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PEPTIDE HORMONES; PROTEINS; RADIOISOTOPES; RODENTS; VERTEBRATES

Optional Information

Notes
10 refs.