Published June 2020 | Version v1
Journal article Metadata-only

Synthesis of deuterium-labeled DL-threo-thiamphenicol

Creators

  • 1. Shenyang Pharmaceutical University, Liaoning (China). Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education
  • 2. Shandong Huijing Biopharmaceutical Technology Co., Ltd, Shandong (China)

Description

A convenient and inexpensive approach for the synthesis of deuterium-labeled thiamphenicol was described. DL-threo-Thiamphenicol-methyl-d3 was prepared with high chemical purity and isotopic enrichment via a six-step process starting from 4-bromobenzaldehyde and DMSO-d6 by employing microwave-assisted copper-mediated methylthiolation and modified Wulff's asymmetric aziridination. (author)

Additional details

Publishing Information

Journal Title
Journal of Radioanalytical and Nuclear Chemistry
Journal Volume
324
Journal Issue
3
Journal Page Range
p. 1463-1467
ISSN
0236-5731
CODEN
JRNCDM

INIS

Country of Publication
Hungary
Country of Input or Organization
Hungary
INIS RN
51108410
Subject category
S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
Descriptors DEI
AMINES; ANTIBIOTICS; DEUTERIUM; LABELLED COMPOUNDS; MICROWAVE RADIATION; SYNTHESIS; THIOLS
Descriptors DEC
ANTI-INFECTIVE AGENTS; DRUGS; ELECTROMAGNETIC RADIATION; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATIONS; STABLE ISOTOPES

Optional Information

Notes
12 refs.