Published September 2006
| Version v1
Journal article
Captive solvent [11C]acetate synthesis in GMP conditions
Creators
- 1. Cyclotron unit of Geneva University Hospitals, Unite Cyclotron, Service de Medecine Nucleaire, Departement de Radiologie et Informatique Medical, Hopital Cantonal de Geneve, CH-1211 Geneva-14 (Switzerland)
Description
Reliable procedure for the production of 1-[11C]acetate in GMP conditions was developed based on a combination of the captive-solvent Grignard reaction conducted in the sterile catheter followed by the convenient solid-phase extraction purification on a series of ion-exchange cartridges. The described procedure proved to be reliable in more than 30 patient productions. The process provides stable radiochemical yields (65% EOB) of sodium acetate (1-[11C]) of the Ph.Eur. quality (radiochemical purity better than 95%) in a short time (5 min)
Additional details
Identifiers
- DOI
- 10.1016/j.apradiso.2006.04.011;
- PII
- S0969-8043(06)00204-1;
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 64
- Journal Issue
- 9
- Journal Page Range
- p. 995-1000
- ISSN
- 0969-8043
- CODEN
- ARISEF
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 38025414
- Subject category
- S07: ISOTOPES AND RADIATION SOURCES;
- Descriptors DEI
- ACETATES; CARBON 11; ION EXCHANGE; LABELLING; PURIFICATION; RADIOPHARMACEUTICALS; SODIUM COMPOUNDS; SOLVENT EXTRACTION; SYNTHESIS
- Descriptors DEC
- ALKALI METAL COMPOUNDS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CARBOXYLIC ACID SALTS; DRUGS; EVEN-ODD NUCLEI; EXTRACTION; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; SEPARATION PROCESSES
Optional Information
- Copyright
- Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.