Published August 2002
| Version v1
Journal article
The application of 99Tcm-MIBI imaging to detect multidrug resistance
Description
Multidrug resistance is the main cause of chemotherapy failure. To detect multidrug resistance is helpful to develop chemotherapy regimens and more effective treatment of patients with tumors. 99Tcm-sestamibi is a transport substrate of mdrl-encoded P-glycoprotein and MRP. The lower 99Tcm -sestamibi accumulation indicates the higher expression of P-glycoprotein in tumor cells. Tt is also related to the expression of MRP. As a result, response to chemotherapy can be estimated before starting treatment by means of 99Tcm-sestamibi imaging and more effective protocol can be chosen
Additional details
Publishing Information
- Journal Title
- Foreign Medical Sciences. Section of Radiation Medicine and Nuclear Medicine
- Journal Volume
- 26
- Journal Issue
- 4
- Journal Page Range
- p. 173-176
- ISSN
- 1001-098X
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 34043915
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CHEMOTHERAPY; DIAGNOSIS; GLYCOPROTEINS; IMAGES; ISONITRILES; MEDICAL EXAMINATIONS; NEOPLASMS; RADIOPHARMACEUTICALS; TECHNETIUM 99
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOHYDRATES; CARBONIC ACID DERIVATIVES; DISEASES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MEDICAL SURVEILLANCE; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SACCHARIDES; TECHNETIUM ISOTOPES; THERAPY; YEARS LIVING RADIOISOTOPES