Evaluation of clinical usefulness of myocardial perfusion imaging with tetrofosmin in patients with ischemic heart disease. Comparison with 201Tl SPECT

We evaluated the clinical usefulness of 99mTc-1, 2-bis[bis(2-ethoxyethyl)phosphino]ethane (tetrofosmin) and compared it with 201Tl. The subjects consisted of 12 patients including 8 patients with old myocardial infarction (OMI), 2 with effort angina, one with stable angina and one with myocarditis. The tetrofosmin SPECT images were obtained during exercise and at rest. The quality of tetrofosmin SPECT images was equal or slightly superior to that of 201Tl. And the sensitivity, specificity and accuracy of tetrofosmin for the detection of coronary stenosis and/or obstruction were equal to that of 201Tl. We conclude that tetrofosmin is useful in the diagnosis of ischemic heart disease. (author)