Published June 2009 | Version v1
Report Metadata-only

Effects of heavy ions on the proliferation and differentiation of mouse melanocytes

Creators

  • 1. National Inst. of Radiological Sciences, Chiba, Chiba (Japan)

Description

Effects of the irradiation of heavy ions on the proliferation and differentiation of embryonic mammalian cells were investigated in this study. We selected melanocytes for this purpose, since melanin synthesis in melanocytes is easily observable in vivo. Pregnant females of C57BL/10J mice crossed with C57BL/10J males were whole-body irradiated with a single acute dose of Fe ions to investigate their effects on embryonic melanoblasts. The effect was studied by scoring changes in the cutaneous coats of F1 offspring 3 weeks after birth. White spots were found in the ventrum and tail tips of the offspring. These results suggest that Fe ions affect the proliferation and differentiation of melanocytes in the mouse skin. (author)

Part of:
2008 Annual report of the research project with heavy ions at NIRS-HIMAC

Additional details

Identifiers

URL
http://id.nii.ac.jp/1657/00073727/;

Publishing Information

Imprint Title
2008 Annual report of the research project with heavy ions at NIRS-HIMAC
Imprint Pagination
349 p.
Journal Page Range
p. 45-46
Report number
NIRS-M--226

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
53066829
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Non-conventional Literature
Descriptors DEI
ANIMAL CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONGENITAL MALFORMATIONS; EMBRYOS; GAMMA RADIATION; HEAVY IONS; HIMAC ACCELERATOR; IRON IONS; MELANIN; MICE; PROGENY; RADIATION DOSES
Descriptors DEC
ACCELERATORS; ANIMALS; CHARGED PARTICLES; CYCLIC ACCELERATORS; DOSES; ELECTROMAGNETIC RADIATION; HEAVY ION ACCELERATORS; HYDROXY COMPOUNDS; IONIZING RADIATIONS; IONS; MALFORMATIONS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PATHOLOGICAL CHANGES; PIGMENTS; RADIATIONS; RODENTS; SYNCHROTRONS; VERTEBRATES

Optional Information

Notes
This record replaces 44074423
Secondary number(s)
HIMAC--132