Published July 1981
| Version v1
Journal article
Synthesis of (2S,5R)-[5-2H]proline
Creators
- 1. Consiglio Nazionale delle Ricerche, Milan (Italy)
- 2. Milan Univ. (Italy)
Description
The title compound was obtained by preferential crystallisation of (2RS,5R)-[52H]proline. The labelled racemic amino acid was synthesized in five steps from (5R)-[52H]-pyrrolidone, which was prepared by cyclisation of (4R)-[4-2H]GABA. The stereospecific label was introduced into GABA enzymatically decarboxylating in 2H2O (2S)-glutamic acid, in the presence of glutamate decarboxylase from E. coli. (author)
Additional details
Publishing Information
- Journal Title
- J. Labelled Compd. Radiopharm.
- Journal Volume
- 18
- Journal Issue
- 7
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 955-962
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 12637481
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CRYSTALLIZATION; DECARBOXYLATION; DEUTERATION; DEUTERIUM COMPOUNDS; LABELLED COMPOUNDS; LABELLING; PROLINE; SYNTHESIS
- Descriptors DEC
- AMINES; AMINO ACIDS; AZOLES; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHASE TRANSFORMATIONS; PYRROLES; PYRROLIDINES