Published June 1984
| Version v1
Journal article
Toxicological study of DTPA as a drug, (2)
- 1. National Inst. of Radiological Sciences, Chiba (Japan)
Description
The chronic side effects of Ca-DTPA and Zn-DTPA were examined in Wistar rats. Ca-DTPA were administered orally to rats for 3 months and Zn-DTPA for 6 months, with 1 or 10 H.D.(H.D.=human dose, 1 H.D.=30μmol/kg body weight), respectively. The hemorrhage or congestion with increase of eosinophils in the lamina propria of the jejunum and ileum was observed in the Ca-DTPA groups at the 1st month after the beginning of administration. On the other hand, no untoward findings were observed in the Zn-DTPA groups throughout the experimental period. As a result, the oral administration of 1 H.D. Zn-DTPA for a long term could estimated to have no side effects in humans from the results in this study. (author)
Additional details
Additional titles
- Subtitle (English)
- Chronic side effects of orally administered DTPA to rats
Publishing Information
- Journal Title
- Hoken Butsuri
- Journal Volume
- 19
- Journal Issue
- 2
- Series
- Hoken Butsuri.
- Journal Page Range
- 119-126
- ISSN
- 0367-6110
- CODEN
- HOKBA
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 17031613
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CALCIUM COMPOUNDS; CHRONIC INTAKE; DECONTAMINATION; DTPA; ORAL ADMINISTRATION; PLUTONIUM COMPOUNDS; RATS; SIDE EFFECTS; TIME DEPENDENCE; TOXICITY; ZINC COMPOUNDS
- Descriptors DEC
- ACTINIDE COMPOUNDS; ALKALINE EARTH METAL COMPOUNDS; AMINO ACIDS; ANIMALS; CARBOXYLIC ACIDS; CHELATING AGENTS; CLEANING; DRUGS; INTAKE; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; TRANSURANIUM COMPOUNDS; VERTEBRATES