Published April 1986 | Version v1
Journal article Metadata-only

Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients

Creators

  • 1. Michael Reese/Univ. of Chicago Center for Radiation Therapy, Chicago, IL

Description

Inherent cellular radioresistance and repair of x-ray damage was studied in 19 early-passage squamous cell carcinoma lines derived from head- and neck-cancer patients with known clinical results following radiotherapy. Human tumor cells that were radioresistant and/or proficient in accumulation/repair of x-ray damage were cultured from patients unsuccessfully treated with radiotherapy. Thus, the presence of radiation-resistant and repair-proficient tumor cells was associated with clinical radiation failure, suggesting the possibility of a predictive assay based on in vitro radiobiological parameters

Additional details

Publishing Information

Journal Title
Proc. Natl. Acad. Sci. U.S.A
Journal Issue
no.8
Series
Proc. Natl. Acad. Sci. U.S.A.
ISSN
0027-8424
CODEN
PNASA

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
17082242
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; CARCINOMAS; DNA REPAIR; HEAD; NECK; PATIENTS; RADIOSENSITIVITY; RADIOTHERAPY; SIDE EFFECTS; TUMOR CELLS
Descriptors DEC
ANIMAL CELLS; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; BODY; BODY AREAS; DISEASES; MEDICINE; NEOPLASMS; RADIATION EFFECTS; THERAPY