Published August 2006 | Version v1
Journal article Metadata-only

Synthesis and labelled with 99Tcm of serotonin (5-HT1A) receptor imaging agent

Creators

  • 1. Jiangsu Inst. of Nuclear Medicine, Wuxi (China)

Description

The synthesis and labelled with 99Tcm of serotonin (5-HT1A) receptor imaging agent derived from way-100635 are reported. The precursor is synthesized by chlorization of N2S2 and condensation with 2-(1-piperazino) phenol, then reduction and deprotection are carried. The labelling ratio is over 90% and the radiochemical purity is over 95% determined by thin layer chromatography (TLC). (authors)

Additional details

Publishing Information

Journal Title
Journal of Isotopes
Journal Volume
19
Journal Issue
3
Journal Page Range
p. 150-153
ISSN
1000-7512

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
38083156
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CHEMICAL PREPARATION; CONTRAST MEDIA; EFFICIENCY; IMPURITIES; LABELLING; PHENOL; PIPERAZINES; PRECURSOR; RECEPTORS; SEROTONIN; SULFUR NITRIDES; TECHNETIUM 99; THIN-LAYER CHROMATOGRAPHY
Descriptors DEC
AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZINES; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHROMATOGRAPHY; DRUGS; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INDOLES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEMBRANE PROTEINS; NEUROREGULATORS; NITRIDES; NITROGEN COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHENOLS; PNICTIDES; PROTEINS; PYRAZINES; PYRROLES; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; SEPARATION PROCESSES; SULFUR COMPOUNDS; SYMPATHOMIMETICS; SYNTHESIS; TECHNETIUM ISOTOPES; TRYPTAMINES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
1 fig., 7 refs.