Published April 2007 | Version v1
Journal article Metadata-only

Investigation of direct and indirect interaction of DNA damage induced by high LET 7Li ions

Creators

  • 1. China Inst. of Atomic Energy, Beijing (China)
  • 2. Hebei Univ. of Technology, Tianjin (China). School of Science
  • 3. The Key Laboratory of Beam Technology and Modification of Ministry of Education, Beijing Normal Univ., Beijing (China)

Description

In order to investigate the direct and indirect interaction of DNA damage induced by high LET heavy ions as well as the protective function of scavenger by means of atomic force microscopy, samples of pUC19 plasmid DNA aqueous solution, pUC19 plasmid DNA aqueous solution with scavenger (mannitol) and dry DNA are irradiated by 7Li ions from the HI-13 Tandem accelerator in China Institute of Atomic Energy (CIAE). Results show that the indirect interaction of free radical plays an important role in DNA strand break induced by 7Li ions and mannitol can protect the DNA molecules effectively. (authors)

Additional details

Publishing Information

Journal Title
Nuclear Techniques
Journal Volume
30
Journal Issue
4
Journal Page Range
p. 250-254
ISSN
0253-3219

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
39114860
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ALCOHOLS; AQUEOUS SOLUTIONS; ATOMIC FORCE MICROSCOPY; CIAE; DNA DAMAGES; FUNCTIONS; HEAVY IONS; INTERACTIONS; IRRADIATION; LET; LITHIUM 7; LITHIUM IONS; MOLECULES; RADICALS; RADIOLYSIS; SCAVENGING; STRAND BREAKS; TANDEM ELECTROSTATIC ACCELERATORS; WATER
Descriptors DEC
ACCELERATORS; CHARGED PARTICLES; CHEMICAL RADIATION EFFECTS; CHEMICAL REACTIONS; CHINESE ORGANIZATIONS; DECOMPOSITION; DISPERSIONS; DNA DAMAGES; ELECTROSTATIC ACCELERATORS; ENERGY TRANSFER; HOMOGENEOUS MIXTURES; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; IONS; ISOTOPES; LIGHT NUCLEI; LITHIUM ISOTOPES; MICROSCOPY; MIXTURES; NATIONAL ORGANIZATIONS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; RADIATION EFFECTS; SOLUTIONS; STABLE ISOTOPES

Optional Information

Notes
6 figs., 11 refs.